Therapeutic Vaccination With Recombinant Adenovirus Reduces Splenic Parasite Burden in Experimental Visceral Leishmaniasis
نویسندگان
چکیده
منابع مشابه
Therapeutic Vaccination With Recombinant Adenovirus Reduces Splenic Parasite Burden in Experimental Visceral Leishmaniasis
Therapeutic vaccines, when used alone or in combination therapy with antileishmanial drugs, may have an important place in the control of a variety of forms of human leishmaniasis. Here, we describe the development of an adenovirus-based vaccine (Ad5-KH) comprising a synthetic haspb gene linked to a kmp11 gene via a viral 2A sequence. In nonvaccinated Leishmania donovani-infected BALB/c mice, H...
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Therapeutic option for visceral leishmaniasis (VL), a potentially fatal disease prevalent in India, is limited. Successful chemotherapy with long lasting protection is ensured when the parasite clearance is associated with the induction of Th1 mediated proinflammatory immune response. Search for novel drugs utilizing natural products is considered beneficial. In the present study oral treatment...
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Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeutic compounds. In the present study, the therapeutic potential and toxicity of ursolic acid (UA), isolated from the leaves of Baccharis uncinella C. DC. (Aste...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 2012
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jir842